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Radosveta Koldamova, MD, PhD
Professor130 DeSoto Street, Pittsburgh 15261
Room 4135, Public Health Building
Pittsburgh, PA 15261
Phone: (412) 383-7197
Email: radak@pitt.edu
Education
Publications
Grants
Education
- 1994 PhD in Biology, Experimental Cancer Therapy, Bulgarian Academy of Sciences, Sofia, Bulgaria
- 1979 MD, Medical Academy, Sofia, Bulgaria
Publications
- Fitz NF, Nam KN, Koldamova R, Lefterov I
Therapeutic targeting of nuclear receptors, liver X and retinoid X receptors, for Alzheimer's disease.
Br J Pharmacology. 2019 Sep; 176(18):3599-3610.
DOI:10.1111/bph.14668 PMID:30924124 - Nam KN, Wolfe CM, Fitz NF, Letronne F, Castranio EL, Mounier A, Schug J, Lefterov I, Koldamova R
Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice.
Biochim Biophys Acta Mol Basis Dis. 2018 Jan; 1864(1):152-161.
DOI:10.1016/j.bbadis.2017.10.018. PMID:29038051 - Castranio EL, Wolfe CM, Nam KN, Letronne F, Fitz NF, Lefterov I, Koldamova R
ABCA1 haplodeficiency affects the brain transcriptome following traumatic brain injury in mice expressing human APOE isoforms.
Acta Neuropathol Commun. 2018 Jul 26; 6(1):69.
DOI:10.1186/s40478-018-0569-2 PMID:30049279 - Wolfe CM, Fitz NF, Nam KN, Lefterov I, Koldamova R.
The Role of APOE and TREM2 in Alzheimer's Disease-Current Understanding and Perspectives.
Int J Mol Sci. 2018 Dec 26; 20(1).
DOI:10.3390/ijms20010081 PMID:30587772 - Carter AY, Letronne F, Fitz NF, Mounier, A, Wolfe CM, Nam KN, Reeves VL, Kamboh H, Lefterov I, Koldamova R
Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice.
PLoS One. 2017 Feb 27; 12(2):e0172161.
DOI:10.1371/journal.pone.0172161 PMID:28241068 - Nam KN, Mounier A, Wolfe CM, Fitz NF, Carter AY, Castranio EL, Kamboh HI, Reeves VL, Wang J, Han X, Schug J, Lefterov I, Koldamova R
Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice.
Sci Rep. 2017 Jun 27; 7(1):4307.
DOI:10.1038/s41598-017-04412-2 PMID:28655926 - Castranio EL, Mounier A, Wolfe CM, Nam KN, Fitz NF, Letronne F, Schug J, Koldamova R, Lefterov I
Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury.
Neurobiol Dis. 2017 Sep; 105:1-14.
DOI:10.1016/j.nbd.2017.05.006 PMID:28502803 - Fitz NF, Carter AY, Tapias V, Castranio EL, Kodali R, Lefterov I, Koldamova R
ABCA1 Deficiency Affects Basal Cognitive Deficits and Dendritic Density in Mice.
J Alzheimers Dis. 2017; 56(3):1075-1085.
DOI:10.3233/JAD-161056 PMID:28106559 - Nam KN, Mounier A, Fitz NF, Wolfe C, Schug J, Lefterov I, Koldamova R.
RXR controlled regulatory networks identified in mouse brain counteract deleterious effects of Aβ oligomers.
Scientific Reports. 2016 Apr 7; 6:24048.
DOI:10.1038/srep24048 PMID:27051978 - Sweet RA, MacDonald ML, Kirkwood CM, Ding Y, Schempf T, Jones-Laughner J, Kofler J, Ikonomovic MD, Lopez OL, Garver ME, Fitz NF, Koldamova R, Yates NA.
Apolipoprotein E*4 (APOE*4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease.
Mol Cell Proteomics. 2016 Jul; 15(7):2252-62.
DOI:10.1074/mcp.M115.056580 PMID:27103636 - Lefterov I, Schug J, Mounier A, Nam KN, Fitz NF, Koldamova R
RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment.
Neurobiol Dis. 2015 Oct; 82:132-140.
DOI:10.1016/j.nbd.2015.05.019 PMID:26071899 - Fitz NF, Tapias V, Cronican AA, Castranio EL, Saleem M, Carter AY, Lefterova M, Lefterov I, Koldamova R
Opposing effects of Apoe/Apoa1 double deletion on amyloid-β pathology and cognitive performance in APP mice.
Brain. 2015 Dec; 138(Pt 12):3699-715.
DOI:10.1093/brain/awv293 PMID:26510953 - Lefterov I, Koldamova R
Metabolic Disorders and Neurodegeneration, introduction to the special issue.
Neurobiol Dis. 2014 Dec; 72 Pt A:1-2.
DOI:10.1016/j.nbd.2014.09.018 PMID:25301714 - Koldamova R, Fitz NF, Lefterov I.
ATP-binding cassette transporter A1: From metabolism to neurodegeneration.
Neurobiology of Disease 2014; 72:13-12.
DOI:10.1016/j.nbd.2014.05.007 PMID:24844148 - Fitz NF, Castranio EL, Carter AY, Kodali R, Lefterov I, Koldamova R.
Improvement of memory deficits and amyloid-β clearance in aged APP23 mice treated with a combination of anti-amyloid-β antibody and LXR agonist.
Journal of Alzheimer's Disease 2014; 41(2):535-549.
DOI:10.3233/JAD-132789 PMID:24643138 - Koldamova R, Schug J, Lefterova M, Cronican AA, Fitz NF, Davenport FA, Carter A, Castranio EL, Lefterov I.
Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration.
Neurobiology of Disease 2014; 63:107-114.
DOI:10.1016/j.nbd.2013.11.005 PMID:24269917 - Fitz NF, Cronican AA, Lefterov I, Koldamova R.
Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".
Science 2013; 340(6135):924-c.
DOI:10.1126/science.1235809 PMID:23704552 - Cronican AA, Fitz NF, Carter A, Saleem M, Shiva S, Barchowsky A, Koldamova R, Schug J, Lefterov I.
Genome-wide alteration of histone H3K9 acetylation pattern in mouse offspring prenatally exposed to arsenic.
PLoS One 2013; 8(2):e53478.
DOI:10.1371/journal.pone.0053478 PMID:23405071 - Fitz NF, Cronican AA, Saleem M, Fauq AH, Chapman R, Lefterov I, Koldamova R.
Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice.
Journal of Neuroscience 2012; 32(38):13125-13136.
DOI:10.1523/JNEUROSCI.1937-12.2012 PMID:22993429 - Lefterov I, Fitz NF, Cronican AA, Fogg A, Lefterov P, Kodali R, Wetzel R, Koldamova R.
Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1ΔE9 mice.
Journal of Biological Chemistry 2010; 285(47):36945-36957.
DOI:10.1074/jbc.M110.127738 PMID:20739292 - Koldamova R, Fitz NF, Lefterov I.
The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration.
Biochimica et Biophysica Acta 2010; 1801(8):824-830.
DOI:10.1016/j.bbalip.2010.02.010 PMID:20188211 - Fitz NF, Cronican A, Pham T, Fogg A, Fauq AH, Chapman R, Lefterov I, Koldamova R.
Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice.
Journal of Neuroscience 2010; 30(20):6862-6872.
DOI:10.1523/JNEUROSCI.1051-10.2010 PMID:20484628 - Cronican AA, Fitz NF, Pham T, Fogg A, Kifer B, Koldamova R, Lefterov I.
Proton pump inhibitor lansoprazole is a nuclear liver X receptor agonist.
Biochemical Pharmacology 2010; 79(9):1310-1316.
DOI:10.1016/j.bcp.2009.12.018 PMID:20060385 - Lefterov I, Fitz NF, Cronican A, Lefterov P, Staufenbiel M, Koldamova R.
Memory deficits in APP23/Abca1+/- mice correlate with the level of Aβ oligomers.
ASN Neuro 2009; 1(2):e00006.
DOI:10.1042/AN20090015 PMID:19570031 - Cohen AD, Ikonomovic MD, Abrahamson EE, Paljug WR, Dekosky ST, Lefterov IM, Koldamova RP, Shao L, Debnath ML, Mason NS, Mathis CA, Klunk WE.
Anti-amyloid effects of small molecule Aβ-binding agents in PS1/APP mice.
Letters in Drug Design and Discovery 2009; 6(6):437-444.
DOI:10.2174/157018009789057526 PMID:20119496 - Lefterov I, Bookout A, Wang Z, Staufenbiel M, Mangelsdorf D, Koldamova R.
Expression profiling in APP23 mouse brain: inhibition of Aβ amyloidosis and inflammation in response to LXR agonist treatment.
Molecular Neurodegeneration 2007; 2:20.
DOI:10.1186/1750-1326-2-20 PMID:17953774 - Koldamova R, Lefterov I.
Role of LXR and ABCA1 in the pathogenesis of Alzheimer's disease - implications for a new therapeutic approach.
Current Alzheimer Research 2007; 4(2):171-178.
DOI:10.2174/156720507780362227 PMID:17430243 - Koldamova RP, Lefterov IM, Staufenbiel M, Wolfe D, Huang S, Glorioso JC, Walter M, Roth MG, Lazo JS.
The liver X receptor ligand T0901317 decreases amyloid β production in vitro and in a mouse model of Alzheimer's disease.
Journal of Biological Chemistry 2005; 280(6):4079-4088.
DOI:10.1074/jbc.M411420200 PMID:15557325 - Koldamova R, Staufenbiel M, Lefterov I.
Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice.
Journal of Biological Chemistry 2005; 280(52):43224-43235.
DOI:10.1074/jbc.M504513200 PMID:16207713 - Klunk WE, Lopresti BJ, Ikonomovic MD, Lefterov IM, Koldamova RP, Abrahamson EE, Debnath ML, Holt DP, Huang GF, Shao L, DeKosky ST, Price JC, Mathis CA.
Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-β in Alzheimer's disease brain but not in transgenic mouse brain.
Journal of Neuroscience 2005; 25(46):10598-10606.
DOI:10.1523/JNEUROSCI.2990-05.2005 PMID:16291932 - Koldamova RP, Lefterov IM, Ikonomovic MD, Skoko J, Lefterov PI, Isanski BA, DeKosky ST, Lazo JS.
22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid β secretion.
Journal of Biological Chemistry 2003; 278(15):13244-13256.
DOI:10.1074/jbc.M300044200 PMID:12547833 - Lazo JS, Ducruet AP, Koldamova RP.
Sleuthful pharmacology.
Molecular Pharmacology 2003; 64(2):199-201.
DOI:10.1124/mol.64.2.199 PMID:12869623 - Lefterov IM, Koldamova RP, Lefterova MI, Schwartz DR, Lazo JS.
Cysteine 73 in bleomycin hydrolase is critical for amyloid precursor protein processing.
Biochemical and Biophysical Research Communications 2001; 283(4):994-999.
DOI:10.1006/bbrc.2001.4860 PMID:11350084 - Koldamova RP, Lefterov IM, Lefterova MI, Lazo JS.
Apolipoprotein A-I directly interacts with amyloid precursor protein and inhibits Aβ aggregation and toxicity.
Biochemistry 2001; 40(12):3553-3560.
DOI:10.1021/bi002186k PMID:11297421 - Gadjeva V, Koldamova R.
Spin-labeled 1-alkyl-1-nitrosourea synergists of antitumor antibiotics.
Anti-Cancer Drug Design 2001; 16(4-5):247-253.
PMID:12049483 - Lefterov IM, Koldamova RP, Lazo JS.
Human bleomycin hydrolase regulates the secretion of amyloid precursor protein.
FASEB Journal 2000; 14(12):1837-1847.
DOI:10.1096/fj.99-0938com PMID:10973933 - Koldamova RP, Lefterov IM, DiSabella MT, Almonte C, Watkins SC, Lazo JS.
Human bleomycin hydrolase binds ribosomal proteins.
Biochemistry 1999; 38(22):7111-7117.
DOI:10.1021/bi990135l PMID:10353821 - Lefterov IM, Koldamova RP, King J, Lazo JS.
The C-terminus of human bleomycin hydrolase is required for protection against bleomycin-induced chromosomal damage.
Mutation Research 1998; 421(1):1-7.
DOI:10.1016/S0027-5107(98)00148-1 PMID:9748474 - Koldamova RP, Lefterov IM, Gadjeva VG, Lazo JS.
Essential binding and functional domains of human bleomycin hydrolase.
Biochemistry 1998; 37(8):2282-2290.
DOI:10.1021/bi9722204 PMID:9485374 - Koldamova RP, Lefterov IM, DiSabella MT, Lazo JS.
An evolutionarily conserved cysteine protease, human bleomycin hydrolase, binds to the human homologue of ubiquitin-conjugating enzyme 9.
Molecular Pharmacology 1998; 54(6):954-961.
DOI:10.1124/mol.54.6.954 PMID:9855622 - Lefterov IM, Koldamova RP.
Schedule dependent variation in human lymphocyte sensitivity to bleomycin and repair of chromosomal aberrations in G2.
Mutation Research 1992; 284(2):195-204.
DOI:10.1016/0027-5107(92)90003-K PMID:1281270 - Koldamova RP, Lefterov IM.
Synergistic effect of CCNU and bleomycin on human lymphocytes exposed at late G1 and G2 states of the cell cycle.
Mutation Research 1991; 260(3):265-269.
DOI:10.1016/0165-1218(91)90035-K PMID:1714541
- May 1, 2013 - Apr 1, 2016
NIH-minority supliment 1R01AG037481-01A1 by NIH: National Institute on Aging
Role: Primary Investigator
"LXR and Human ApoE Isoform Effects on AD " - Apr 1, 2013 - Mar 31, 2016
R01AG037481-01A1 NIH/NIA
Role: Primary Investigator
"LXR and Human ApoE Isoform Effects on AD "
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