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Nicholas F. Fitz, PhD
Research Assistant Professor130 DeSoto Street, Pittsburgh 15261
Room 4136, Public Health Building
Pittsburgh, PA 15261
Phone: (412) 383 7818
Email: nffitz@pitt.edu
- 2008 PhD in Pharmacology and Toxicology, Duquesne University Mylan School of Pharmacy
- 2001 BS in Animal Bioscience, Pennsylvania State University
Publications
- Fitz NF, Nam KN, Koldamova R, Lefterov I
Therapeutic targeting of nuclear receptors, liver X and retinoid X receptors, for Alzheimer's disease.
Br J Pharmacology. 2019 Sep; 176(18):3599-3610.
DOI:10.1111/bph.14668 PMID:30924124 - Nam KN, Wolfe CM, Fitz NF, Letronne F, Castranio EL, Mounier A, Schug J, Lefterov I, Koldamova R
Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice.
Biochim Biophys Acta Mol Basis Dis. 2018 Jan; 1864(1):152-161.
DOI:10.1016/j.bbadis.2017.10.018. PMID:29038051 - Castranio EL, Wolfe CM, Nam KN, Letronne F, Fitz NF, Lefterov I, Koldamova R
ABCA1 haplodeficiency affects the brain transcriptome following traumatic brain injury in mice expressing human APOE isoforms.
Acta Neuropathol Commun. 2018 Jul 26; 6(1):69.
DOI:10.1186/s40478-018-0569-2 PMID:30049279 - Wolfe CM, Fitz NF, Nam KN, Lefterov I, Koldamova R.
The Role of APOE and TREM2 in Alzheimer's Disease-Current Understanding and Perspectives.
Int J Mol Sci. 2018 Dec 26; 20(1).
DOI:10.3390/ijms20010081 PMID:30587772 - Carter AY, Letronne F, Fitz NF, Mounier, A, Wolfe CM, Nam KN, Reeves VL, Kamboh H, Lefterov I, Koldamova R
Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice.
PLoS One. 2017 Feb 27; 12(2):e0172161.
DOI:10.1371/journal.pone.0172161 PMID:28241068 - Nam KN, Mounier A, Wolfe CM, Fitz NF, Carter AY, Castranio EL, Kamboh HI, Reeves VL, Wang J, Han X, Schug J, Lefterov I, Koldamova R
Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice.
Sci Rep. 2017 Jun 27; 7(1):4307.
DOI:10.1038/s41598-017-04412-2 PMID:28655926 - Castranio EL, Mounier A, Wolfe CM, Nam KN, Fitz NF, Letronne F, Schug J, Koldamova R, Lefterov I
Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury.
Neurobiol Dis. 2017 Sep; 105:1-14.
DOI:10.1016/j.nbd.2017.05.006 PMID:28502803 - Fitz NF, Carter AY, Tapias V, Castranio EL, Kodali R, Lefterov I, Koldamova R
ABCA1 Deficiency Affects Basal Cognitive Deficits and Dendritic Density in Mice.
J Alzheimers Dis. 2017; 56(3):1075-1085.
DOI:10.3233/JAD-161056 PMID:28106559 - Nam KN, Mounier A, Fitz NF, Wolfe C, Schug J, Lefterov I, Koldamova R
RXR controlled regulatory networks identified in mouse brain counteract deleterious effects of Aβ oligomers.
Sci Rep. 2016 Apr 7; 6:24048.
DOI:10.1038/srep24048 PMID:27051978 - Sweet RA, MacDonald ML, Kirkwood CM, Ding Y, Schempf T, Jones-Laughner J, Kofler J, Ikonomovic MD, Lopez OL, Garver ME, Fitz NF, Koldamova R, Yates NA.
Apolipoprotein E*4 (APOE*4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease.
Mol Cell Proteomics. 2016 Jul; 15(7):2252-62.
DOI:10.1074/mcp.M115.056580 PMID:27103636 - Mounier A, Georgiev D, Nam KN,Fitz NF, Castranio EL, Wolfe CM, Cronican AA, Schug J, Lefterov I,Koldamova R.
Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity.
Journal of Neuroscience. 2015 Aug 26; 35(34):11862-76.
DOI:10.1523/JNEUROSCI.1001-15.2015 PMID:26311769
- Lefterov I, Schug J, Mounier A, Nam KN, Fitz NF, Koldamova R
RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment.
Neurobiol Dis. 2015 Oct; 82:132-140.
DOI:10.1016/j.nbd.2015.05.019 PMID:26071899 - Fitz NF, Tapias V, Cronican AA, Castranio EL, Saleem M, Carter AY, Lefterova M, Lefterov I, Koldamova R
Opposing effects of Apoe/Apoa1 double deletion on amyloid-β pathology and cognitive performance in APP mice.
Brain. 2015 Dec; 138(Pt 12):3699-715.
DOI:10.1093/brain/awv293 PMID:26510953 - Fitz NF, Castranio EL, Carter AY, Kodali R, Lefterov I, Koldamova R.
Improvement of memory deficits and amyloid-β clearance in aged APP23 mice treated with a combination of anti-amyloid-β antibody and LXR agonist.
Journal of Alzheimer's Disease 2014; 41(2):535-549.
DOI:10.3233/JAD-132789 PMID:24643138 - Koldamova R, Fitz NF, Lefterov I.
ATP-binding cassette transporter A1: From metabolism to neurodegeneration.
Neurobiology of Disease 2014; 72:13-21.
DOI:10.1016/j.nbd.2014.05.007 PMID:24844148 - Koldamova R, Schug J, Lefterova M, Cronican AA, Fitz NF, Davenport FA, Carter A, Castranio EL, Lefterov I.
Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration.
Neurobiology of Disease 2014; 63:107-114.
DOI:10.1016/j.nbd.2013.11.005 PMID:24269917 - Cronican AA, Fitz NF, Carter A, Saleem M, Shiva S, Barchowsky A, Koldamova R, Schug J, Lefterov I.
Genome-wide alteration of histone H3K9 acetylation pattern in mouse offspring prenatally exposed to arsenic.
PLoS One 2013; 8(2):e53478.
DOI:10.1371/journal.pone.0053478 PMID:23405071 - Fitz NF, Cronican AA, Lefterov I, Koldamova R.
Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".
Science 2013; 340(6135):924-c.
DOI:10.1126/science.1235809 PMID:23704552 - Babalola PA, Fitz NF, Gibbs RB, Flaherty PT, Li PK, Johnson DA.
The effect of the steroid sulfatase inhibitor (p-O-sulfamoyl)-tetradecanoyl tyramine (DU-14) on learning and memory in rats with selective lesion of septal–hippocampal cholinergic tract.
Neurobiology of Learning and Memory 2012; 98(3):303-310.
DOI:10.1016/j.nlm.2012.09.003 PMID:23022361 - Fitz NF, Cronican AA, Saleem M, Fauq AH, Chapman R, Lefterov I, Koldamova R.
Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice.
Journal of Neuroscience 2012; 32(38):13125-13136.
DOI:10.1523/JNEUROSCI.1937-12.2012 PMID:22993429 - Fitz NF, Cronican A, Pham T, Fogg A, Fauq AH, Chapman R, Lefterov I, Koldamova R.
Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice.
Journal of Neuroscience 2010; 30(20):6862-6872.
DOI:10.1523/JNEUROSCI.1051-10.2010 PMID:20484628 - Koldamova R, Fitz NF, Lefterov I.
The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration.
Biochimica et Biophysica Acta 2010; 1801(8):824-830.
DOI:10.1016/j.bbalip.2010.02.010 PMID:20188211 - Lefterov I, Fitz NF, Cronican AA, Fogg A, Lefterov P, Kodali R, Wetzel R, Koldamova R.
Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1ΔE9 mice.
Journal of Biological Chemistry 2010; 285(47):36945-36957.
DOI:10.1074/jbc.M110.127738 PMID:20739292
Grants
- Apr 1, 2014 - Apr 1, 2019
K01 Mentored Development Award KAG044490A by NIH: National Institute on Aging
Role: Primary Investigator
"Peripheral and Brain Cholesterol Metabolism in Neurodegenerative Mouse Models" - Jan 1, 2013 - Jun 1, 2015
Foundation Research Grant: Alzheimer's Association
Role: Primary Investigator
"Potential of RXR Agonists as Alzheimer’s Disease Therapeutics"
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