University of Pittsburgh

The Koldamova/ Lefterov Lab

 

Research in Koldamova & Lefterov Laboratory




The research in Koldamova & Lefterov Laboratory is supported by NIH/NIA, NIH/NIEHS, DoD and private sources.

  1. Fitz NF, Nam KN, Koldamova R, and Lefterov I.
    Therapeutic targeting of nuclear receptors, liver X and retinoid X receptors, for Alzheimer's disease.
    Br J Pharmacol 2019 Sep; 176(18): 3599-3610.
    PMID:30924124
  2. Castranio EL, Wolfe CM, Nam KN, Letronne F, Fitz NF, Lefterov I, and Koldamova R.
    ABCA1 haplodeficiency affects the brain transcriptome following traumatic brain injury in mice expressing human APOE isoforms.
    Acta Neuropathol Commun 2018 Jul 26; 6(1): 69.
    PMID:30049279
  3. Nam KN, Wolfe CM, Fitz NF, Letronne F, Castranio EL, Mounier A, Schug J, Lefterov I, and Koldamova R.
    Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice.
    Biochim Biophys Acta Mol Basis Dis 2018 Jan; 1864(1): 152-161.
    PMC:29038051
  4. Wolfe CM, Fitz NF, Nam KN, Lefterov I, and Koldamova R.
    The Role of APOE and TREM2 in Alzheimer's Disease-Current Understanding and Perspectives.
    Int J Mol Sci 2018 Dec 26; 20(1).
    PMID:30587772
  5. Carter, A. Y., F. Letronne, N. F. Fitz, A. Mounier, C. M. Wolfe, K. N. Nam, V. L. Reeves, H. Kamboh, I. Lefterov and R. Koldamova
    Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice.
    PLoS One 2017; 12(2): e0172161
    PMID:28241068
  6. Castranio, E. L., A. Mounier, C. M. Wolfe, K. N. Nam, N. F. Fitz, F. Letronne, J. Schug, R. Koldamova and I. Lefterov
    Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury.
    Neurobiol Dis 2017; 105: 1-14.
    PMID:28502803
  7. Cronican, A. A., N. F. Fitz, A. Carter, M. Saleem, S. Shiva, A. Barchowsky, R. Koldamova, J. Schug and I. Lefterov.
    ABCA1 Deficiency Affects Basal Cognitive Deficits and Dendritic Density in Mice.
    J Alzheimers Dis. 2017
    PMID:23405071
  8. Nam KN, Mounier A, Wolfe CM, Fitz NF, Carter AY, Castranio EL, Kamboh HI, Reeves VL, Wang J, Han X, Schug J, Lefterov I, and Koldamova R.
    Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice.
    Sci Rep 2017 Jun 27; 7(1): 4307.
    PMC:28655926
  9. Nam, K. N., A. Mounier, N. F. Fitz, C. Wolfe, J. Schug, I. Lefterov and R. Koldamova.
    RXR controlled regulatory networks identified in mouse brain counteract deleterious effects of Abeta oligomers.
    Sci Rep 2016; 6: 24048
    PMC:4823697
  10. Sweet, R. A., M. L. MacDonald, C. M. Kirkwood, Y. Ding, T. Schempf, J. Jones-Laughner, J. Kofler, M. D. Ikonomovic, O. L. Lopez, M. E. Garver, N. F. Fitz, R. Koldamova and N. A. Yates.
    Apolipoprotein E*4 (APOE*4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease.
    Mol Cell Proteomics 2016; 15(7): 2252-2262.
    PMID:27103636
  11. Fitz, N. F., V. Tapias, A. A. Cronican, E. L. Castranio, M. Saleem, A. Y. Carter, M. Lefterova, I. Lefterov and R. Koldamova.
    Opposing effects of Apoe/Apoa1 double deletion on amyloid-beta pathology and cognitive performance in APP mice.
    Brain 2015; 138(Pt 12): 3699-3715.
    PMID:26510953
  12. Lefterov, I., J. Schug, A. Mounier, K. N. Nam, N. F. Fitz and R. Koldamova.
    RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment.
    Neurobiol Dis 2015; 82: 132-140.
    PMID:26071899
  13. Mounier, A., D. Georgiev, K. N. Nam, N. F. Fitz, E. Castranio, C. Wolfe, A. A. Cronican, J. Schug, I. Lefterov and R. Koldamova.
    Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity.
    Journal of Neuroscience 2015; 35(34): 11862-11876.
    PMID:26311769
  14. Fitz, N. F., E. L. Castranio, A. Y. Carter, R. Kodali, I. Lefterov and R. Koldamova.
    Improvement of memory deficits and amyloid-beta clearance in aged APP23 mice treated with a combination of anti-amyloid-beta antibody and LXR agonist.
    J Alzheimers Dis 2014; 41(2): 535-549.
    PMID:24643138
  15. Koldamova, R., N. F. Fitz and I. Lefterov.
    ATP-binding cassette transporter A1: from metabolism to neurodegeneration.
    Neurobiol Dis 2014; 72 Pt A: 13-21.
    PMID:24844148
  16. Koldamova, R., J. Schug, M. Lefterova, A. A. Cronican, N. F. Fitz, F. A. Davenport, A. Carter, E. L. Castranio and I. Lefterov.
    Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration.
    Neurobiol Dis 2014; 63: 107-114.
    PMID:24269917
  17. Lefterov, I. and R. Koldamova.
    Metabolic Disorders and Neurodegeneration, introduction to the special issue.
    Neurobiol Dis 2014; 72 Pt A: 1-2.
    PMID:25301714
  18. Fitz, N. F., A. Y. Carter, V. Tapias, E. L. Castranio, R. Kodali, I. Lefterov and R. Koldamova.
    Genome-wide alteration of histone H3K9 acetylation pattern in mouse offspring prenatally exposed to arsenic.
    PLoS One 2013; 8(2): e53478.
    PMID:28106559
  19. Fitz, N. F., A. A. Cronican, I. Lefterov and R. Koldamova.
    Comment on "ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models.
    JScience 2013; 340(6135): 924-c.
    PMC:PMC4086452
  20. Fitz, N. F., A. A. Cronican, M. Saleem, A. H. Fauq, R. Chapman, I. Lefterov and R. Koldamova.
    Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice.
    J Neurosci 2012; 32(38): 13125-13136.
    PMID:22993429