University of Pittsburgh

The Koldamova/ Lefterov Lab

 

Publications

  • Fitz, N. F., J. Wang, M. I. Kamboh, R. Koldamova and I. Lefterov (2021). "Small nucleolar RNAs in plasma extracellular vesicles and their discriminatory power as diagnostic biomarkers of Alzheimer's disease." Neurobiology of Disease 159: 105481.
  • Fitz, N. F., K. N. Nam, C. M. Wolfe, F. Letronne, B. E. Playso, B. E. Iordanova, T. D. Y. Kozai, R. J. Biedrzycki, V. E. Kagan, Y. Y. Tyurina, X. Han, I. Lefterov and R. Koldamova (2021). "Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease." Nature Communications 12(1): 3416.
  • Fitz, N. F., C. M. Wolfe, B. E. Playso, R. J. Biedrzycki, Y. Lu, K. N. Nam, I. Lefterov and R. Koldamova (2020). "Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice." Mol Neurodegener 15(1): 41.
  • Fitz, N. F., K. N. Nam, R. Koldamova and I. Lefterov (2019). "Therapeutic targeting of nuclear receptors, liver X and retinoid X receptors, for Alzheimer's disease." Br J Pharmacol 176(18): 3599-3610.
  • Lefterov, I., C. M. Wolfe, N. F. Fitz, K. N. Nam, F. Letronne, R. J. Biedrzycki, J. Kofler, X. Han, J. Wang, J. Schug and R. Koldamova (2019). "APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain." Alzheimers Res Ther 11(1): 113.
  • Castranio, E. L., C. M. Wolfe, K. N. Nam, F. Letronne, N. F. Fitz, I. Lefterov and R. Koldamova (2018). "ABCA1 haplodeficiency affects the brain transcriptome following traumatic brain injury in mice expressing human APOE isoforms." Acta Neuropathologica Communications 6(1).
  • Nam, K. N., C. M. Wolfe, N. F. Fitz, F. Letronne, E. L. Castranio, A. Mounier, J. Schug, I. Lefterov and R. Koldamova (2018). "Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice." Biochim Biophys Acta Mol Basis Dis 1864(1): 152-161.
  • Wolfe, C., N. Fitz, K. Nam, I. Lefterov and R. Koldamova (2018). "The Role of APOE and TREM2 in Alzheimer′s Disease—Current Understanding and Perspectives." International Journal of Molecular Sciences 20(1): 81.
  • Nam, K. N., A. Mounier, C. M. Wolfe, N. F. Fitz, A. Y. Carter, E. L. Castranio, H. I. Kamboh, V. L. Reeves, J. Wang, X. Han, J. Schug, I. Lefterov and R. Koldamova (2017). "Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice." Sci Rep 7(1): 4307.